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Cardiovasc Toxicol 18:459470 Tahir M, Saleem A, Akhtar MF (2025) Diosgenin loaded-chitosan biodegradable nanoparticles ameliorate adjuvant-induced arthritis, pain, and peripheral neuropathy through moderation of inflammatory and oxidative stress biomarkers

Acute use of this drug in animal models has been seen to reverse several characteristics of senescent fibroblasts,84 protect against UV radiation damage,85 and reinitiate fibroblast proliferation.84 Metformin has also shown senomorphic effects in lung fibroblasts.86 Flavonoids and plant extracts such as Solidago virgaurea extracts, are capable of modulating cellular senescence.82 Senolytics and senomorphics are promising new agents in the field of human aging, but clinical studies are needed to evaluate their true effectiveness and safety

FIRST GENERATION SIDE EFFECTS Chlorpropamide can induce hyponatremia and water retention due to inappropriate secretion of antidiuretic hormone (ADH) (20)

Glutathione dosing must be personalized based on health goals